M.Sc. Module organiser: Advanced Training in Molecular Biology


Click here From Harvard – The inner life of the Cell and more.

Click here From WEHI malaria life cycle and more.

Click here for Animations of PCR and other molecular biology techniques.

Click here for Phage infection animation

Click here for Cell Biology animations

Click here for Immunology animations

Lectures 2011-2012:

Antigenic Variation in Plasmodium falciparum Infected Erythrocytes (3160)

Selected reading:

  • Miller et al (2002) The pathogenic basis of malaria. Nature 415:673-9
  • Deitsch & Hviid (2004) Variant surface antigens, virulence genes and the pathogenesis of malaria. Trends in Parasitol 20:562-66
  • Kraemer & Smith (2006) A family affair: var genes, PfEMP1 binding, and malaria disease. Curr. Opin. Microbiol. 4:374-80
  • Scherf et al (2008) Antigenic variation in Plasmodium falciparum. Ann. Rev. Microbiol. 62:445-70

P. falciparum life cycle: Animation

Introduction to 3158 module (3158)
Mon 20th Feb: 10.30 am.

Structure and Organisation of Chromosomes (3158)
Tue 28th Feb: 11 am.

Selected reading:

  • Book chapter: The flow of genetic information PDF

Chromatin packaging animation
Additional animations

Epigenetic control of gene expression (3158)
Wed 7th Mar: 11 am.

  • Riddihough, G & Zahn, LM. (2010) What Is Epigenetics? Science 330:611.
  • Janicki et al., (2004) From silencing to gene expression: real-time analysis in single cells. Cell. 116:683-98.Paper and movies

Basic epigenetics animation

X inactivation animation

Review of 3158 module – write-up (3158)
Mon 12th Mar: 11am.

Trypanosome Molecular Biology: Antigenic Variation in Trypanosoma brucei (3160)
Thu 15th Mar: 3.30 pm.

Selected reading:

  • Pays (2005) Regulation of antigen gene expression in Trypanosoma brucei. Trends Parasitol 21:517-20.
  • Baral TN et al., (2006) Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. Nature Med. 12:580-4.
  • Taylor JE and Rudenko G. (2006) Switching trypanosome coats: what’s in the wardrobe? Trends Genet. 22:614-20.
  • TriTryp sequencing papers: 2005 in Science

Antimicrobial Chemotherapy – syndicate (3169)
Thu 5th May: 11am.

Selected reading:

  • Bray et al (2003) Pentamidine uptake and resistance in pathogenic protozoa. Trends Parasitol 5:232-9
  • Gelb et al (2003) Protein farnesyl and N-myristoyl transferases. Mol Biochem Parasitol 126:155-63
  • Smith et al (2004) GPI biosynthesis as a drug target against African sleeping sickness. EMBO J 23:4701-8
  • Cowman & Crabb (2003) Functional genomics: identifying drug targets for parasitic diseases. Trends Parasitol 11:538-43
  • Gelb & Hol (2002) Drugs to combat tropical protozoan parasites. Science 297:343-4

Gene Expression in Prokaryotes and Eukaryotes (C3333)
African Trypanosomaiasis: Life Cycle and Pathology (3122)

Essays & Tutorials

Click here to access online versions of Molecular Biology of the Cell, Alberts et al, Molecular Cell Biology, Lodish et al, and several other textbooks

Access Ben Lewin’s Ergito / Virtual Text site here. Includes Genes 2000 and 100 essays on “great experiments”

Click here for NCBI tutorials on Bioinformatics

Access information on the Cell Nucleus here

Click here for additional online lectures, graphics and animations