{"id":1342,"date":"2017-03-05T23:41:07","date_gmt":"2017-03-05T22:41:07","guid":{"rendered":"http:\/\/blogs.lshtm.ac.uk\/alsfordlab\/?p=1342"},"modified":"2018-05-18T11:37:40","modified_gmt":"2018-05-18T10:37:40","slug":"old-projects-come-to-fruition-in-2016","status":"publish","type":"post","link":"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2017\/03\/05\/old-projects-come-to-fruition-in-2016\/","title":{"rendered":"Old projects come to fruition in 2016"},"content":{"rendered":"<p>After leaving <a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/david-horn\/home\" target=\"_blank\" rel=\"noopener\">David Horn&#8217;s lab<\/a> almost four years ago in August 2013,\u00a0when David and his group moved to the University of Dundee, we&#8217;re still managing to publish papers together. That&#8217;s the consequence of spending\u00a0ten years in the same small but very productive group that also maintains great collaborative relationships &#8211; you get\u00a0to be involved in multiple projects and, the best part, see them come to fruition! 2016 saw two such papers &#8211; Lucy and Seb&#8217;s on <a title=\"PubMed\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27226299\" target=\"_blank\" rel=\"noopener\">Vex1<\/a>, and the <a title=\"PubMed\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27625397\" target=\"_blank\" rel=\"noopener\">NUP2<\/a>\u00a0work by Luke Maishman and colleagues in <a href=\"http:\/\/fieldlab.org\/Welcome.html\" target=\"_blank\" rel=\"noopener\">Mark Field&#8217;s group<\/a>.<\/p>\n<p>Vex1 is a key\u00a0controller of <em>VSG<\/em> monoallelic gene expression in <em>Trypanosoma brucei<\/em>; it localises close to the site of RNA polymerase I mediated <em>VSG<\/em> transcription, the expression site body.\u00a0Remarkably, depletion or overexpression of Vex1 leads to loss of monoallelic control, indicating its fundamental role in controlling this process.<\/p>\n<p>NUP2 is a second component of the <em>T. brucei<\/em> nuclear lamina, which interacts with <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22479148\" target=\"_blank\" rel=\"noopener\">NUP1<\/a> to form a basket-like structure under the nuclear membrane, essential for nuclear integrity and apropriate gene expression regulation. These\u00a0proteins, though exhibiting functional conservation, are highly divergent from the nuclear lamins of the Ophistokonta, which includes several of the standard model organisms (<em>S. cerevisiae<\/em>, <em>C. elegans<\/em>, <em>X. Laevis<\/em>, <em>D. melanogaster<\/em>, as well as us!). This is yet another confirmation of the benefit of exploring beyond the narrow confines of the Ophistokonta!\u00a0Not only can we find many disease-causing organisms in the other groups (Excavata &#8211; <em>T. brucei<\/em>; Alveolates [SAR] &#8211; <em>Plasmodium<\/em>), but we also gain fascinating evolutionary insights through their study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>After leaving David Horn&#8217;s lab almost four years ago in August 2013,\u00a0when David and his&#8230;<\/p>\n","protected":false},"author":116,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12450],"tags":[],"class_list":["post-1342","post","type-post","status-publish","format-standard","hentry","category-publication","odd"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Old projects come to fruition in 2016 - Alsford Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2017\/03\/05\/old-projects-come-to-fruition-in-2016\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Old projects come to fruition in 2016 - Alsford Lab\" \/>\n<meta property=\"og:description\" content=\"After leaving David Horn&#8217;s lab almost four years ago in August 2013,\u00a0when David and his...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2017\/03\/05\/old-projects-come-to-fruition-in-2016\/\" \/>\n<meta property=\"og:site_name\" content=\"Alsford Lab\" \/>\n<meta property=\"article:published_time\" content=\"2017-03-05T22:41:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-05-18T10:37:40+00:00\" \/>\n<meta name=\"author\" content=\"Sam Alsford\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sam Alsford\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2017\/03\/05\/old-projects-come-to-fruition-in-2016\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2017\/03\/05\/old-projects-come-to-fruition-in-2016\/\"},\"author\":{\"name\":\"Sam Alsford\",\"@id\":\"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/#\/schema\/person\/5005c5aa631c3c4da712ea95e66f76cd\"},\"headline\":\"Old projects come to fruition in 2016\",\"datePublished\":\"2017-03-05T22:41:07+00:00\",\"dateModified\":\"2018-05-18T10:37:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2017\/03\/05\/old-projects-come-to-fruition-in-2016\/\"},\"wordCount\":268,\"articleSection\":[\"Publication\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2017\/03\/05\/old-projects-come-to-fruition-in-2016\/\",\"url\":\"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2017\/03\/05\/old-projects-come-to-fruition-in-2016\/\",\"name\":\"Old projects come to fruition in 2016 - 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