{"id":1443,"date":"2018-05-02T14:23:10","date_gmt":"2018-05-02T13:23:10","guid":{"rendered":"http:\/\/blogs.lshtm.ac.uk\/alsfordlab\/?p=1443"},"modified":"2018-06-13T13:47:14","modified_gmt":"2018-06-13T12:47:14","slug":"presenting-our-work-at-the-bsp-in-aberystwyth","status":"publish","type":"post","link":"https:\/\/blogs.lshtm.ac.uk\/alsfordlab\/2018\/05\/02\/presenting-our-work-at-the-bsp-in-aberystwyth\/","title":{"rendered":"Presenting our work at the BSP in Aberystwyth"},"content":{"rendered":"

Juan, Aboagye and I spent several days on Welsh coast at the British Society for Parasitology’s spring meeting in Aberystwyth. Not the easiest place to get to from London, but definitely worth it – a nice location and a great meeting. It was good to be able to present our recently published apoL1 work<\/a> and to get useful feedback on other ongoing projects.<\/p>\n

Aboagye presented some of his PhD work exploring the anti-trypanosomal activity of Zanthoxylum zanthoxyloides<\/em> extracts. Aboagye has just returned to the University of Ghana, Legon, after a four month visit to the lab. While at LSHTM, Aboagye used our RNAi library system to start decoding the parasite proteins that drive the anti-trypanosomal activity of several plant-derived compounds.<\/p>\n

Juan presented his latest data exploring the regulation of rDNA<\/em> array transcription. Having noted several years ago that only a subset of rDNA<\/em> spacer loci in T. brucei<\/em> are capable of supporting high level ectopic expression, we speculated that this might reflect the activity of the associated rDNA<\/em> arrays, indicating that only a subset may be active at a time. By integrating reporters into several rDNA<\/em> contexts, Juan has confirmed that not all rDNA<\/em> arrays are equally active and has generated a tool set that will enable us to analyse their transcriptional regulation.<\/p>\n

Appropriate regulation of rRNA transcription is fundamental to all living systems. However, it’s of particular importance to African trypanosomes, as uniquely amongst studied eukaryotes, RNA polymerase I also transcribes a subset of mRNAs (those for the abundant surface proteins, VSG and procyclin). Thus, these parasites may be exquisitely sensitive to changes in the optimal distribution of RNA polymerase I between competing mRNA and rRNA transcriptional pools.<\/p>\n","protected":false},"excerpt":{"rendered":"

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