New paper out in Scientific Reports

Our work ” Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival” has been published in Scientific Reports.

We have challenged M. tuberculosis with nitric oxide and interrogated the dynamic transcriptome and proteome response through time resolved analysis.  Our findings suggest that whilst the early transcriptome changes might contribute to late-stage recovery, the initial resistance and survival of M. tuberculosis to nitric oxide is contingent on mechanisms other than transcriptional regulation.

You can find out more and access the full-text  here.

Translation UK 2017

From the 6th to the 7th of July, Beth and I attended the Translation UK meeting in Nottingham.

Beth presented her work on ribosome profiling

EMBO Tuberculosis Conference 2016

From 19th to 23rd September, we all attended the EMBO Tuberculosis Conference at the Pasteur Institute in Paris.

Anna presented a poster summarising her work on translational reporters

Postdoctoral position available

A postdoctoral research fellow position is now available in my group. Find out more at LSHTM Jobs.

Research Assistant position available

A Research Assistant position is now available in my research group. Vacancy details available at LSHTM Jobs. Please, contact me directly with any queries.

TB bacteria missing genetic signposts for proteins during latent infection

We have applied genome-wide mapping of transcriptional start sites combined with RNA sequencing and Shotgun proteomics in the human pathogen Mycobacterium tuberculosis, and discovered that more than a quarter of the bacterial genes are lacking the canonical bacterial signal for translation initiation. This could have important implications in the way translation is regulated in this pathogen, in particular during latent infection.

Read more about this story at the Francis Crick Institute news page here