Inclusion and Exclusion Criteria

Inclusion criteria

  1. Patients aged 18 years and above.
  2. Written informed consent to participate.
  3. Patients undergoing Coronary Artery Bypass Graft (CABG) surgery on Cardiopulmonary bypass (CPB) with or without valve surgery.
  4. Additive European System for Cardiac Operative Risk Evaluation (EuroSCORE) of 5 or higher (higher scores indicating a greater risk of death; 0 indicates minimum risk and ≥6 indicates high risk).

Exclusion criteria

  1. Pregnant or lactating women.
  2. Allergy to propofol.
  3. Previous diagnosis or suspected malignant hyperthermia.
  4. Patients with a known sensitivity to any of the IMPs or other halogenated anaesthetics.
  5. Concomitant therapy with Glibenclamide, Allopurinol, Theophylline or Nicorandil (medications that may interfere with remote ischemic preconditioning).
  6. Inclusion in another clinical trial of an investigational medicinal product within the last 3 months.

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