Our work ” Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival” has been published in Scientific Reports.
We have challenged M. tuberculosis with nitric oxide and interrogated the dynamic transcriptome and proteome response through time resolved analysis. Our findings suggest that whilst the early transcriptome changes might contribute to late-stage recovery, the initial resistance and survival of M. tuberculosis to nitric oxide is contingent on mechanisms other than transcriptional regulation.
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