TB bacteria missing genetic signposts for proteins during latent infection

We have applied genome-wide mapping of transcriptional start sites combined with RNA sequencing and Shotgun proteomics in the human pathogen Mycobacterium tuberculosis, and discovered that more than a quarter of the bacterial genes are lacking the canonical bacterial signal for translation initiation. This could have important implications in the way translation is regulated in this pathogen, in particular during latent infection.

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