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PhD studentship available within the MRC London Intercollegiate Doctoral Training Partnership (MRC LID) between The London School of Hygiene and Tropical Medicine (LSHTM) and St. George’s University of London (SGUL)

The PhD Project title is “Using functional genomics to understand the manipulation of host cell responses during Mycobacterium tuberculosis infection” and will be supervised by Dr. Axel Nohturfft (primary supervisor – SGUL), Prof. Steve Goodbourn (SGUL) and Dr. Teresa Cortes (LSHTM). Deadline for applications is on Sunday 14th January.

More information about the project and application process can be found here

Congratulations to Beth for securing funding for her public engagement project ” Secret Agents 005“!

In collaboration with scientists from UCL, she will take science to the streets to inspire primary school children that careers in science are fun and within their reach.

Our work ” Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival” has been published in Scientific Reports.

We have challenged M. tuberculosis with nitric oxide and interrogated the dynamic transcriptome and proteome response through time resolved analysis.  Our findings suggest that whilst the early transcriptome changes might contribute to late-stage recovery, the initial resistance and survival of M. tuberculosis to nitric oxide is contingent on mechanisms other than transcriptional regulation.

You can find out more and access the full-text  here.

We have applied genome-wide mapping of transcriptional start sites combined with RNA sequencing and Shotgun proteomics in the human pathogen Mycobacterium tuberculosis, and discovered that more than a quarter of the bacterial genes are lacking the canonical bacterial signal for translation initiation. This could have important implications in the way translation is regulated in this pathogen, in particular during latent infection.

Read more about this story at the Francis Crick Institute news page here

A Research Assistant position is now available in my research group. Vacancy details available at LSHTM Jobs. Please, contact me directly with any queries.

A postdoctoral research fellow position is now available in my group. Find out more at LSHTM Jobs.