Author Archives: Sam Alsford

Y11/12 Research Experience @LSHTM

With the recent lifting of COVID19 restrictions, Matt Rogers and I were finally able to run our two-day summer research experience workshop for the first time since 2018! On 28th and 29th June we joined by three groups of enthusiastic … Continue reading

Decoding anti-leishmanial drug efficacy determinants.

After a couple of months on BioRxiv our first pre-print has been accepted for publication in Antimicrobial Agents & Chemotherapy! ‘Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei‘ Selecting our T. brucei RNAi library … Continue reading

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A-level research workshop: molecules, cells and flies

Matt Rogers and I ran our annual research workshop for first-year A-level students on 28-29th June. This time students from St Thomas the Apostle School and 6th Form College joined fellow students from Dulwich College. All told, we had 15 … Continue reading

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Presenting our work at the BSP in Aberystwyth

Juan, Aboagye and I spent several days on Welsh coast at the British Society for Parasitology’s spring meeting in Aberystwyth. Not the easiest place to get to from London, but definitely worth it – a nice location and a great … Continue reading

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Amino acid transport and drug efficacy

Back in 2012, we published our study decoding the anti-T. brucei drug efficacy determinants – or parasite proteins critical to drug action, such as drug transporters and activators. This identified a slew of proteins that drive the action of the … Continue reading

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Welcoming Juan Macedo to the lab

Dr Juan Macedo joined the lab on the 7th March, supported by a Swiss National Science Foundation early mobility post-doctoral fellowship. Juan has spent the last few years at the University of Bern working with Peter Butikofer and Doris Rentsch … Continue reading

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The 34th annual SwissTryp meeting in Leysin

Thanks to Pascal Maser (SwissTPH) for inviting me to present our latest apoL1 and anti-leishmanial drug RNAi library findings at the 2017 SwissTryp meeting in Leysin, Switzerland (11th-13th January, 2017). It was a great opportunity to hear about some of the … Continue reading

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Old projects come to fruition in 2016

After leaving David Horn’s lab almost four years ago in August 2013, when David and his group moved to the University of Dundee, we’re still managing to publish papers together. That’s the consequence of spending ten years in the same small but … Continue reading

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Ubiquitination influences suramin efficacy

Suramin is one of the oldest drugs still in use today – it’s been used to treat early stage human African trypanosomiasis caused by T. b. rhodesiense since the early 1920s. Back in 2012 we showed that suramin uptake was dependent on … Continue reading

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DELTAS programme at WACCBIP, University of Ghana

On the 12th/13th November the WACCBIP DELTAS programme inception meeting took place in the Biochemistry, Cell & Molecular Biology department at the University of Ghana, Accra. This five year programme led by Dr Gordon A. Awandare is funded by the … Continue reading

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