The Gates Malaria Partnership (GMP) 2001-2005 supported the Moshi vector research site (established in March 2003) and the construction of biotechnology laboratories at KCMC and NIMR. GMP laid the foundations for high quality research directly related to the prevention of malaria and PAMVERC was established in 2008
We’re based at 3 sites in Tanzania:
- Mwanza, Mwanza Region
- Moshi, Kilimanjaro Region
- Muheza, Tanga Region
From 2011-2018 we worked in Muleba, Kagera Region. The Muleba site, located in North-West Tanzania on the shores of Lake Victoria was coordinated largely by staff based at KCMUCo and is an ideal place to evaluate non-pyrethroid products against highly pyrethroid-resistant mosquitoes.
The site experiences high malaria prevalence and has experienced epidemics in the recent past. Universal coverage of LLINs was rolled out in 2011, and there has been annual spraying of IRS with lamdacyhalothrin 2007-11 and bendiocarb in 2012. Anopheles gambiae s.s. predominates and has multiple insecticide-resistance mechanisms (both kdr and metabolic based resistance) that confer a high level of resistance to all pyrethroids and to DDT, and increasing resistance to bendiocarb.
Two cluster randomised control trials have been conducted in 161 villages in the Muleba district by PAMVERC since 2011. In 2011-2012 a combination of IRS with the carbamate insecticide bendiocarb and Olyset® Net were tested (1) and in 2015-2016 the combination of organophosphate IRS using Actellic CS (Syngeta), a microencapsulation formulation of pirimiphos-methyl and Olyset® Net and Olyset® Plus (Sumitomo Chemicals, Japan), containing 2% permethrin and 1% PBO. Houses in the study are set individually and has mud, brick or cement walls and thatched or metal roofs. The insecticide susceptibility status of bed bugs has not been evaluated to date.
1 Combination of Insecticide Treated Nets and Indoor Residual Spraying in Northern Tanzania Provides Additional Reduction in Vector Population Density and Malaria Transmission Rates Compared to Insecticide Treated Nets Alone: A Randomised Control Trial Protopopoff N, Wright A, West PA, Tigererwa R, Mosha FW, et al. (2015) Combination of Insecticide Treated Nets and Indoor Residual Spraying in Northern Tanzania Provides Additional Reduction in Vector Population Density and Malaria Transmission Rates Compared to Insecticide Treated Nets Alone: A Randomised Control Trial. PLOS ONE 10(11): e0142671. https://doi.org/10.1371/journal.pone.0142671
2 Effectiveness of a long-lasting piperonyl butoxide-treated insecticidal net and indoor residual spray interventions, separately and together, against malaria transmitted by pyrethroid-resistant mosquitoes: a cluster, randomised controlled, two-by-two factorial design trial. Natacha Protopopoff, Jacklin F Mosha, Eliud Lukole, Jacques D Charlwood, Alexandra Wright, Charles D Mwalimu, Alphaxard Manjurano, Franklin W Mosha, William Kisinza, Immo Kleinschmidt, Mark Rowland. The Lancet, Volume 391, Issue 10130, 2018, Pages 1577-1588, ISSN 0140-6736, https://doi.org/10.1016/S0140-6736(18)30427-6.