• AMTNET face-to-face meeting in Lilongwe, January 2018

  • Dr. David Meya (IDI Uganda PI) at the AMTNET face-to-face meeting in Lilongwe, January 2018

  • Dr. Henry Mwandumba (MLW PI) at the AMTNET face-to-face meeting in Lilongwe, January 2018

  • Dr. Sayoki Mfinanga speaking at the face-to-face AMTNET meeting in Lilongwe, January 2018

  • The team enjoying themselves at the AMTNET face-to-face meeting, Lilongwe, January 2018

  • Dr. Admire Hlupeni (UoZ Study Doctor) at the AMTNET face-to-face meeting in Lilongwe, January 2018.

  • Prof. Mina Hosseinipour showing AMTNET delegates around UNC Project Malawi, January 2018.

  • Health Economics Course at Ryalls Hotel, Blantyre, Malawi, November 2017.

  • AMBITION Trial Manager and Lead Clinician meet with Dr. Henry Mwandumba (MLW PI) in Blantyre, October 2017

  • First AMBITION Investigators’ Meeting, May 2017, Gaborone


AMBITION (High Dose AMBISOME on a Fluconazole Backbone for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: A Randomised Controlled Non-inferiority Trial) is a four-year project funded at just under €10M by the European and Developing Countries Clinical Trials Partnership, the Swedish International Development Agency and the DFID/MRC/Wellcome Trust Joint Global Health Trials Fund. It runs from 1 January 2017 – 31 December 2020 across a consortium of five European and six African partners.

The Phase III clinical trial will recruit 850 patients at our six African sites. It is the largest clinical trial for HIV-associated cryptococcal meningitis ever to be conducted.

A number of other activities run alongside the trial, including economic cost-effectiveness analyses, laboratory-based sub-studies, and training and capacity building events. An African Meningitis Trials Network (AMTNET) has also been established, which seeks to provide a framework for future clinical trials to investigate urgently needed novel treatments and diagnostics strategies aimed at reducing the morbidity and mortality due to meningitis in Africa. It is envisaged that AMTNET will continue to operate long after completion of AMBITION.

AMBITION is co-ordinated by The London School of Hygiene and Tropical Medicine, UK. Our African collaborating institutions and recruiting sites are shown below.

Recruitment Update:

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