• AMBITION Investigators’ Meeting (2019)

    Delegates were treated to a guided tour of the Institut Pasteur Museum.

  • UNC Project Malawi Team, May 2020

    The UNC Project Malawi team assemble for a group shot in May 2020, while observing suitable social distancing practices.

  • AMBITION Investigators’ Meeting (2019)

    Delegates enjoyed a packed two-day meeting at Institut Pasteur, Paris, from 28-29 May 2019.

  • AMBITION Investigators’ Meeting (2019)

    Dr. Timothy Kachitosi (Study Doctor at UNC Project Malawi) leads a presentation about participant recruitment in Lilongwe.

  • Medical Mycology Course 2018, Cape Town

    Delegates enjoy a brief respite from their packed week of teaching and debate, hosted by the University of Cape Town from 10-14 December 2018.

  • Medical Mycology Course 2018, Cape Town

    Tshepiso Mbangiwa (AMBITION PhD Scholar) discusses laboratory activities with delegates from Botswana, South Africa, Malawi and Tanzania.

  • Medical Mycology Course 2018, Cape Town

    Dr. Dea Garcia-Hermoso (Institut Pasteur) and Tshepiso Mbangiwa (AMBITION PhD Scholar) prepare the laboratory sessions at the University of Cape Town, 10-14 December 2018.

  • Medical Mycology Course 2018, Cape Town

    Delegates from Uganda and Tanzania became acquainted at the University of Cape Town in December 2018.

  • Medical Mycology Course 2018, Cape Town

    Dr. Elvis Temfack (Faculty) and delegates from Cameroon and Nigeria at the University of Cape Town in December 2018.

  • Dr. Tinevimbo Shiri visits BHP, January 2019

    Dr. Tinevimbo Shiri (Health Economist, LSTM) visits the AMBITION team in Gaborone to deliver lectures and lead discussions on the Health Economics sub-study and on economic evaluations of clinical trials.

  • AMBITION monitoring visit in Harare

    Prof. Rati Ndhlovu (AMBITION PI, University of Zimbabwe) chairs a meeting during the first study monitoring visit in October 2018.

  • Keeping busy with patient enrolment and care in Uganda

    Sister Jane Frances and Sister Florence prepare AMBITION study drugs at Kiruddu General Hospital, Kampala (October 2018).

  • AMBITION site initiation visit, Blantyre

    AMBITION teams from Blantyre and Lilongwe convened in Blantyre from 28-29 August 2018 for the site initiation visit.

  • AMBITION Site Initiation Visit, Kampala

    The recruiting site in Kampala, Uganda, hosted their site initiation visit in August 2018.

  • AMBITION Site Initiation Visit, Harare

    The AMBITION site in Harare opened to recruitment in July 2018.

  • AMBITION Site Initiation Visit, Harare

    Dr. Tawanda Zinyandu (AMBITION Study Doctor, UoZ) and Prof. Joe Jarvis conclude the Site Initiation Visit in July 2018.

  • AMBITION Site Initiation Visit, Cape Town

    The AMBITION site in Cape Town opened to recruitment in June 2018.

  • AMBITION Investigators’ Meeting (2018)

    Enjoying discussions at Woburn House, London, in May 2018.

  • AMBITION Investigators Meeting (2018)

    Prof. Olivier Lortholary (Institut Pasteur) and Prof. Graeme Meintjes (UCT) enjoy catching up in London in May 2018.

  • AMBITION Investigators’ Meeting (2018)

    Delegates enjoyed two days of discussions and presentations at Woburn House in London.

  • AMBITION Investigators’ Meeting (2018)

    Dr. Edward Mpoza (IDI Uganda) and Dr. David Lawrence (LSHTM) share a dish during the second AMBITION Investigators’ Meeting in London, May 2018.

  • AMBITION GCP & Clinical Trials Course, Gaborone

    Delegates from all AMBITION recruiting sites convened in Gaborone in March 2018 for a week of intensive training on Good Clinical Practice and Clinical Trials.

  • AMBITION GCP & Clinical Trials Course (Gaborone)

    Delegates enjoyed working in groups to apply some of the principles learned during the lecture-based sessions from 12-16 March 2018.

  • AMNET Meeting, January 2018

    The Steering Committee convened in Lilongwe from 30-31 January 2018 for the first AMNET face-to-face meeting.

  • AMNET Meeting (January 2018)

    Dr. David Meya lends to the discussions in Lilongwe, January 2018.

  • AMNET Meeting (January 2018)

    Members of the AMNET Steering Committee enjoyed an initial face-to-face meeting in January 2018 hosted by UNC Project Malawi in Lilongwe.

  • AMNET Meeting, January 2018

    Dr. Henry Mwandumba (MLW AMBITION PI) lends to the discussions.

  • AMBITION Health Economics Course (November 2017)

    Delegates from across the AMBITION Consortium convened in Blantyre for an intensive Health Economics course led by Prof. Louis Niessen from LSTM.

  • Site visit to MLW (2017)

    Prof. Henry Mwandumba hosts Dr. Nabila Youssouf and Dr. David Lawrence for a pre-recruitment site visit in November 2017.

  • AMBITION Investigators’ Meeting (2017)

    Colleagues from across the AMBITION Consortium convened in Gaborone for a kick-off meeting in May 2017.


AMBITION (High Dose AMBISOME on a Fluconazole Backbone for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: A Randomised Controlled Non-inferiority Trial) is a four-year project funded at €10M by the European and Developing Countries Clinical Trials Partnership, the Swedish International Development Agency and the DFID/MRC/Wellcome Trust Joint Global Health Trials Fund. It runs from 1 January 2017 – 30 June 2021 across a consortium of six African and five European partners.

The Phase III clinical trial (AMBITION-cm) is the largest clinical trial for HIV-associated cryptococcal meningitis ever to be conducted. The trial completed recruitment in February 2021. We are grateful to everyone who has enabled us to achieve this; our exceptionally dedicated study teams who have provided an outstanding level of care, all participants and their families, and other senior investigators and individuals who have contributed in numerous ways including participating in the TSC and DMC, lending expertise to our portfolio of capacity-strengthening events, developing our Electronic Data Capture Tool and undertaking data analysis.

A number of other activities run alongside the trial, including economic cost-effectiveness analyses, laboratory-based sub-studies and capacity building events. AMNET (African Meningitis Network) has been established to provide a solid framework to facilitate future clinical trials to investigate urgently-needed novel treatments and diagnostics strategies aimed at reducing the morbidity and mortality due to meningitis in Africa.

AMBITION is co-ordinated by The London School of Hygiene and Tropical Medicine, UK. African collaborating institutions (where participants were recruited, in conjunction with local hospitals) are shown below.

The AMBITION consortium is extremely grateful to the following funders:

…and to Gilead, who has donated the AmBisome for the clinical trial.

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