We are particularly interested in the transport of the trypanolytic factors (TLFs) from the flagellar pocket to the lysosome (their point of action), and the proteins and pathways involved in this process. Work by others has shown that TLF1 enters the cell via the TbHpHb receptor, and that ApoL1 (a component of TLF1/2) causes cell lysis by forming pores in the lysosomal membrane, while the expression of the serum resistance antigen renders T. b. rhodesisense resistant to human serum. However, there are significant gaps in our knowledge about this process and the means by which African trypanosomes can become resistant to lysis by human serum. For example, how does TLF2 enter the cell? What components of the cell’s endocytic machinery are responsible for the intracellular transit of TLF to the lysosome? How is the lytic component (ApoL1) released from the TLF particle? What is the molecular basis for T. b. gambiense resistance to TLF/ApoL1? Though changes in the TbHpHb receptor seem to be involved, this isn’t the whole story.
Bioinformatics
Trypanosomatid Biology
Trypanosomatid labs - International
- Alena Zíková
- Bibo Li
- Christian Janzen
- Christian Tschudi
- Christine Clayton
- Derrick Robinson
- Doris Rentsch
- Etienne Pays
- Eva Gluenz
- Frederic Bringaud
- George Cross
- Gerald Spaeth
- Isabel Roditi
- Jay Bangs
- Jayne Raper
- Jean-Claude Dujardin
- Julius Lukeš
- Ken Stuart
- Kent Hill
- Klaus Ersfeld
- Kojo Mensah-Wilmot
- Lucy Glover
- Luísa Figueiredo
- Luise Krauth-Siegel
- Marilyn Parsons
- Markus Engstler
- Megan Povelones
- Mélanie Bonhivers
- Michael Boshart
- Michael Duszenko
- Michael Pollastri
- Michelle Klingbeil
- Miguel Navarro
- Minu Chaudhuri
- Nicolai Siegel
- Noreen Williams
- Pascal Maser
- Patrick Bastien
- Peter Bütikofer
- Peter Myler
- Philippe Bastin
- Robert Jensen
- Roberto Docampo
- Stephen Beverley
- Stephen Hajduk
- Susanne Kramer
- Torsten Ochsenreiter
- Vicky Avery
- Vivian Bellofatto
- Yvon Sterkers
- Ziyin Li
Trypanosomatid labs - UK
- Achim Schnaufer
- Alan Fairlamb
- Alvaro Acosta Serrano
- Annette MacLeod
- Bill Wickstead
- Bungo Akiyoshi
- Catarina Gadelha
- David Horn
- Ed Louis
- Gloria Rudenko
- Harry de Koning
- Jeremy Mottram
- John Kelly
- Karen Grant
- Keith Gull
- Keith Matthews
- Kevin Tyler
- Liam Morrison
- Mark Carrington
- Mark Field
- Martin Llewellyn
- Matt Berriman
- Michael Barrett
- Michael Ferguson
- Michael Ginger
- Mick Urbaniak
- Paul Capewell
- Paul McKean
- Paula MacGregor
- Pegine Walrad
- Richard McCulloch
- Samuel Dean
- Sue Vaughan
- Sue Welburn
- Tansy Hammarton
- Terry Smith
- Wendy Gibson
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