Welcome to the Alsford lab web site…
…where you can find out about our research on the African trypanosome, Trypanosoma brucei. We’re particularly interested in the
parasite’s interaction with its host environment, especially the uptake and sub-cellular transit of host- and parasite-derived molecules,
and the consequences of such encounters for the trypanosome.
Rachel’s paper describing the parasite factors that drive apolipoprotein-L1 action against Trypanosoma brucei brucei is now
available at PLoS Pathogens – highlighting the importance of ubiquitination and membrane trafficking to apoL1 action
The results of our collaborative research with Doris Rentsch’s lab (University of Bern) characterising the Trypanosoma brucei
amino acid transporters, AAT10.1 and AAT2.4, and their roles in ornithine uptake and suramin and eflornithine efficacy is now
available at the FASEB Journal
If you’re interested in using the bloodstream-form Trypanosoma brucei RNAi library in your research, or adapting the RIT-seq
approach to your preferred organism, extensive detailed protocols are available at Nature Protocols
Explore our other pages…
…to find details of our cell lines & plasmids (all freely available to the research community on request), protocols and publications.
There are also extensive links to other online resources and Trypanosomatid research groups based in the UK and beyond. If your lab is
missing from this list (apologies!) or the link is out of date, drop me an email, and I’ll be sure to update the list.
Read our Blog for intermittent postings on publications, research, conferences, and anything else we might have an opinion on – all
(intelligent and informative) comments and contributions welcome!
| T: 020 7927 2699(lab) 020 7927 2352(office) | Lab333, LSHTM, Keppel Street, London WC1E 7HT.
| Pathogen Molecular Biology | Infectious & Tropical Diseases | LSHTM